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以色列Pluristem Therapeutics Inc
luristem Therapeutics, Inc.從事間質(zhì)干細(xì)胞的生產(chǎn)技術(shù)的研究和開發(fā)，以及細(xì)胞療法的產(chǎn)品的商品化。 該公司正開發(fā)一個平臺，這樣設(shè)計是為了創(chuàng)建一個功能干細(xì)胞的生產(chǎn)系統(tǒng)，可以治療重癥血液，心血管疾病，自身免疫性和其它疾病。 它開發(fā)了PluriX Bioreactor系統(tǒng)，該系統(tǒng)的設(shè)計是一個系統(tǒng)的基質(zhì)干細(xì)胞的文化和襯底上，創(chuàng)建一個人工生理環(huán)境下，間質(zhì)干細(xì)胞可以生長和繁殖以外的人體無任何使用外源性生物制品或生物克隆。 該公司成立于2001年，前身是AI Software, Inc.，在2003年公司改名為Pluristem Life Systems, Inc.，后來在2007年11月又改名為Pluristem Therapeutics, Inc.，公司位于以色列的Haifa。

Pluristem Therapeutics Inc. (NASDAQ: PSTI; DAX: PJT) is a bio-therapeutics company dedicated to the commercialization of unrelated donor-patient (allogeneic) cell therapy products for the treatment of several severe degenerative, ischemic and autoimmune disorders. The Company is developing a pipeline of products derived from human placenta, a non-controversial, non-embryonic, adult stem cell source. The (PLacental eXpanded) cell products are stored off-the-shelf, ready-to-use, and require no histocompatibility matching.

These placental adherent stromal cells (ASCs) are expanded in the Company's proprietary PluriXTM 3D bioreactor system, which provides a 3D microenvironment that enables large-scale growth of these cells without the need for supplemental growth factors or other exogenous materials. PLX cells are immune privileged, possess immunomodulatory properties, and are expanded in vitro without showing signs of phenotypic or karyotypic changes. Pluristem believes that the PLX cells?mechanism of action may be related to the secretion of cytokines and/or other potent immune modulators.

Pluristem's first product, PLX-PAD (for the treatment of Peripheral Artery Disease), received from the Food and Drug Administration (FDA) and the Paul Ehrlich Institute (PEI), the German competent authority in the European Union, clearance to begin a 揊irst-In-Human?placental-derived mesenchymal-like stromal cell clinical trial.

Pluristem has offices in the USA with research and manufacturing facilities in Israel.